Confirmed—aging is not gradual—researchers discover that it occurs in two critical bursts at ages 44 and 60, with changes in metabolism, immunity, and cardiac risk

August 30, 2025
Confirmed—aging is not gradual—researchers discover that it occurs in two critical bursts at ages 44 and 60, with changes in metabolism, immunity, and cardiac risk

Aging doesn’t happen as gradually as we think, nor as suddenly as we believe. Many factors influence the passage of time and how it affects each person. These factors include metabolism, kidney health, the immune system, heart disease, and so on. A Stanford University study has revealed that there are significant changes in the risk of skin, muscle, and heart diseases between the ages of 40 and 60.

After studying more than 3,000 different proteins, they identified that the greatest indicator of aging is indeed proteins

The research was conducted at Stanford University, where experts analyzed blood plasma samples from 4,200 people (aged between 18 and 95). After studying more than 3,000 different proteins, they identified that the greatest indicator of aging is indeed proteins. Beginning at age 40, changes in lipid and alcohol metabolism occur, while kidney function, carbohydrate metabolism, and immune regulation decline around age 60.

For most people, their average “healthspan” (the time spent in good health) is 11 to 15 years shorter than their life expectancy

According to research, living a long life isn’t necessarily linked to a healthy and active old age. For most people, their average “healthspan” (the time spent in good health) is 11 to 15 years shorter than their life expectancy, according to Dr. Michael Snyder, senior author of the study and director of the Center for Genomics and Personalized Medicine at Stanford University.

Late Maturity: between 60 and 78 years of age, when cell regeneration slowly declines

With this data, researchers have established three stages: adulthood, from 34 to 60 years of age, when the first signs of wear and tear begin; late maturity, between 60 and 78 years of age, when cell regeneration slowly declines; and finally, old age, from 78 years of age onward, when deterioration is most noticeable and accelerated.

Better health: maintaining a healthy body weight, being physically active, eating a high-quality diet

Previous studies have shown that health in midlife, generally between ages 40 and 65, significantly influences later health. A 2018 study published in the journal Nutrients linked specific lifestyle factors in midlife with better health throughout aging. This lifestyle includes maintaining a healthy body weight, being physically active, eating a high-quality diet, and not smoking or using other drugs.

Gettin older: People have a greater capacity for social interaction, physical activity, and cognitive activity

“We’re increasing in life expectancy, and as people get older, they become healthier and stronger. They have a greater capacity for social interaction, physical activity, and cognitive activity,” said José Augusto García Navarro, president of the Spanish Society of Geriatrics and Gerontology.

“Your health in your 60s, 70s, and 80s is really determined by what you do in the decades before”

This isn’t the first study to highlight, once again, the importance of living a healthy lifestyle. The new study adds to this growing body of research on health span and highlights the importance of developing certain lifestyle habits at a younger age. “Your health in your 60s, 70s, and 80s is really determined by what you do in the decades before,” said Kenneth Boockvar, MD, director of the Comprehensive Center for Aging Research at the University of Alabama at Birmingham, who was not involved in the study.

In any case, we know that nothing can prevent a breakdown in the body’s health, but we do know, thanks to experts, that certain conditions can be prevented by eating a balanced diet, exercising, or engaging in any type of physical activity. Also, thanks to science, we know that taking care of mental health is also essential for improving health and promoting a balanced nervous system.